An integrated \"All India Co-ordinated Research Project for Epidemiological studies on Foot-and-mouth (FMD)\" was started as a \"Regional Research Center\" in 1973 at the Department of Veterinary Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, under ICAR-\"All India Co-ordinated Research Project for FMD virus typing,\" Mukteswar, with the goal of strengthening research on FMD in North East India.
Mandate
Active epidemiological surveillance through regularly monitoring of antigenicity and genomic make up of Foot and Mouth Disease virus strains responsible for disease outbreaks in collaboration with ICAR-National Institute on Foot-and-Mouth disease, Bhubaneswar.
Objective(s)
To conduct systematic epidemiological and molecular epidemiological studies on Foot- and- Mouth Disease (FMD), and also to study carrier status of the infection and latency of the virus. Analysis of economic impact of FMD on livestock industry To act as regional laboratory for FMD in North East India.
Thrust Area
Active and passive surveillance of FMD in North East India in AICRP mode To carryout antigenic and molecular characterization of field isolates. To study molecular epidemiology of FMD in North East India. Confirmatory diagnosis and expert advice. Participation in FMD Control Programme in India with vital contribution in monitoring pre and post vaccinal antibody response for assessment of individual and herd immunity level. FMD Serosurveillance in the region.
1. Studies onimmune and antibodyresponse of FMD polyvalent vaccine in buffalo.
2. Studies on the immune response ofFMD polyvalent vaccine in Pigs.
3. Foot and Mouth Disease virus infections andantibodyresponse inCattle.
4. Antibody response of Foot and Mouth disease and Swine Fever vaccines in Pigs.
5. Evaluation of protectiveantibodyresponseMouthof cattle after Foot and disease vaccination with immunomodulators.
6. IsolationandCharacterizationof FMD virus type 'O' from field outbreaks.
7. Studies on the immune response of cattle vaccinated simultaneously withFMD and Rabies vaccines.
8. Immune response of Yak after FMD vaccination at different time interval.
9. Comparison ofdifferent techniquesfor detection of FMD virusserotype-O from clinical materials.
10. Antigenic relationship of field isolates of FMD virus Type O with vaccine strain.
11. Detection of antibody against structural and non-structuralproteins of FMDvirus indifferentgroups ofanimals.
12. Seroprevalence and molecular screening of PPR and FMD in goats of Assam.
13. Persistence of FMD virus in Cattle.
14. Expression of certaincytokines inrelation to persistence of FMD virus type-O in cattle.
15. Isolation of FMD virus type-O ofbovine and porcine origin in different cell lines and molecular characterization of the adapted virus.
16. Molecular characterization of FootandMouth disease virus isolates from Assam.
Molecular detection and characterization of Foot and Mouth Disease Virus (FMDV), and study of cytokine expressionnaturallyinfectedlocal/cross-bred cattle from Assam.1.
Deka, P., Das, S., Hazarika, R. et al. (2024)
Foot-and-mouth disease-associated myocarditis is age dependent in suckling
calves. Scientific Report 14, 10289 (2024). https://doi.org/10.1038/s41598-024-59324-9
2.
Deka,
P.; Das, C.; 2 , Sharma, K.; Gogoi, S.M.; Borah, B. and Hazarika, A.K. (2018)
Isolation and molecular characterisation of foot-and mouth disease virus
serotype o from pigs, Indian J. Comp. Microbiol. Immunol. Infect. Dis. Vol. 39,
96-101*
3.
Hosamani, M., Gopinath, S., Sreenivasa, B.P. et al. A
new blocking ELISA for detection of foot-and-mouth disease non-structural
protein (NSP) antibodies in a broad host range. Appl Microbiol
Biotechnol 106, 6745–6757 (2022). https://doi.org/10.1007/s00253-022-12151-2
4.
Baro Sangeeta, Sharma Krishna, Borah Biswajyoti, Tamuly
Shantanu, Deka P., Boro Prince, Das S.K. (2018). Molecular epidemiology and
phylogenetic analysis of foot and mouth disease virus type
‘O’ and evaluation of its carrier state in cattle of Assam
by Real time PCR. Indian Journal of Animal Research. 53(11): 1497-1503. doi:
10.18805/ijar.B-3670.
5.
B. Borah, P. Deka, K. Sharma, S. Baro, A. K. Hazarika, C. Das, G. B. Garam, P. Boro, K. Ltu, (2018) Isolation,
identification and retrospective study of foot-and-mouth disease virus from
affected Mithun (Bos frontalis) in north-eastern India, Transboundary
and Emerging Diseases, https://doi.org/10.1111/tbed.12678, Volume65 (1)
6.
Rout,
M., Sharma, K., & Deka, P. (2017). Serological Evidence of Natural Exposure
of Randomly Sampled Pigs of Assam to Foot-and-Mouth Disease Virus. Indian Vet.
J, 94(04), 19-20.
7.
Boro,
P., Sharma, K., Deka, P., Sarma, R., & Sarma, S. (2016). Immune Response of
Yak (Poephagus grunniens) Following Trivalent Oil Adjuvant FMD Vaccination
Along With Immunomodulator. Journal of Animal Research, 6(2), 231-236.
8.
Rout,
M., Garam, G. B., Lama, R., Deka, P., Tripathy, J. P., Giri, P., ... &
Singh, R. P. (2024). Foot-and-mouth disease in mithun, yak, cattle-yak hybrids
and cattle in the north-eastern states of India during 2021-2022.
9.
Rout,
M., Deka, P., Nair, N.S., Karikalan, M., Manjunatha, V., Sahoo, N., Sharma,
A.K., Mohapatra, J.K. and Singh, R.P. (2023). Serological Evidence of
Foot-and-Mouth Disease Virus Nonstructural Protein Antibodies in Indian
Elephants (Elephas maximus indicus). J. Anim. Res., 13(05): 833-837
10.
P.
Bordoloi, K. Sharma, R. Sharma, S. Das (2015), Application of Reverse
Transcription PCR for detection of FMD virus Type "O" in infected and
recovered animals, Journal of Pure 8e Applied Microbiology, 8(4):3367-3372.
11. Barman,
B., Sarma, D. K., Sharma, K., & Barman, N. N. (2014). Antibody response of
pigs vaccinated with FMD and swine fever vaccines*. The Indian Journal of Animal Sciences, 74(5). https://epubs.icar.org.in/index.php/IJAnS/article/view/38620
12. Govindaraj G, Ganeshkumar B, Krishnamohan A, Hegde R,
Nandakumar S, Kokila Prabhakaran, Mohan V, Kakker N, Lokhande T, Sharma K,
Kanani A, Limaye A, Natchimuthu K, Khan TA, Misri J, Dash BB, Pattnaik B and
Rahman H. (2020). Economic Impact of FMD in cattle and buffaloes in India.
Indian Journal of Animal Sciences. 90(7): 971-976.
13. G
Govindaraj, A Krishnamohan, Raveendra Hegde, Nanda Kumar, Kokila Prabhakaran,
Vinay Mohan Wadhwan, Naresh Kakker, T Lokhande, Krishna Sharma, Amit Kanani, K
Natchimuthu, PN Ananth, Arup Kumar De, Tanveer Ahmed Khan, Jyoti Misri, BB
Dash, Bramhadev Pattnaik, Rahman Habibur (2021) Foot and Mouth Disease (FMD)
incidence in cattle and buffaloes and its associated farm-level economic costs
in endemic India, Preventive
Veterinary Medicine, 190, 105318
14. Deka, P. et al.
(2022) Sampling strategy based on lesion ageing: A key concept for right sample
at right time for Foot-and-Mouth disease surveillance. Conference: IAVMI 2022 At:
LUVAS, Hisar
15. Deka, P. et al.
(2015) Incidence, serotyping and epidemiology of Foot and Mouth disease in
Assam. Conference: XXIV National Conference VIROCON 2015At: North Eastern
Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong.
16.
Deka,
P., Sharma, K., Boro, P., Baro, S., Ltu, K., Garam, G. (2016) Isolation and
identificationofFMDV from clinically affected Mithun (Bosfrontalis) in
north-east India., Compendium of Global Symposium on Animal health: Newer
technologies and their applications and XXIXAnnual
convention of IAVMI.
17.
Boro,
P., Baro, S., Deka, P. and Sharma, K. (2016), Retrospective study of FMD
outbreaks by liquid phase blocking ELISA., Compendium of Global Symposium on
Animal health: Newer technologies and their applications and XXIX Annual
convention of IA VMI.
18.
Baro,
S., Deka, P. Sharma, K. and Boro, P. (2016), Detection of FMDV RNA in naturally
infected cattle by RT-PCR, Compendium of Global Symposium on Animal health:
Newer technologies and their applications and XXIX Annual convention of IA VMI.
