An integrated \"All India Co-ordinated Research Project for Epidemiological studies on Foot-and-mouth (FMD)\" was started as a \"Regional Research Center\" in 1973 at the Department of Veterinary Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, under ICAR-\"All India Co-ordinated Research Project for FMD virus typing,\" Mukteswar, with the goal of strengthening research on FMD in North East India.
Mandate
Active epidemiological surveillance through regularly monitoring of antigenicity and genomic make up of Foot and Mouth Disease virus strains responsible for disease outbreaks in collaboration with ICAR-National Institute on Foot-and-Mouth disease, Bhubaneswar.
Objective(s)
Thrust Area
A bi-annual vaccination based FMD Control Programme (FMDCP) was launched by the Government of India in 2004, initially covering 54 districts in the country to control FMD and to minimize the economic loss due to FMD. This involves six monthly FMD vaccination with an inactivated trivalent FMD (O, A and Asia1) vaccine, of all eligible cattle and buffaloes for protection against FMD. The scheme was progressively expanded to cover the entire country by 2018-19. In order to assess the effectiveness of both vaccine and vaccination programme, serum samples before vaccination and 21 to 30 days post vaccination are collected and screened for level of serotype specific structural antibodies by Solid Phase Blocking ELISA (LPB ELISA) developed by ICAR-DFMD.
1. Studies onimmune and antibodyresponse of FMD polyvalent vaccine in buffalo.
2. Studies on the immune response ofFMD polyvalent vaccine in Pigs.
3. Foot and Mouth Disease virus infections andantibodyresponse inCattle.
4. Antibody response of Foot and Mouth disease and Swine Fever vaccines in Pigs.
5. Evaluation of protectiveantibodyresponseMouthof cattle after Foot and disease vaccination with immunomodulators.
6. IsolationandCharacterizationof FMD virus type 'O' from field outbreaks.
7. Studies on the immune response of cattle vaccinated simultaneously withFMD and Rabies vaccines.
8. Immune response of Yak after FMD vaccination at different time interval.
9. Comparison ofdifferent techniquesfor detection of FMD virusserotype-O from clinical materials.
10. Antigenic relationship of field isolates of FMD virus Type O with vaccine strain.
11. Detection of antibody against structural and non-structuralproteins of FMDvirus indifferentgroups ofanimals.
12. Seroprevalence and molecular screening of PPR and FMD in goats of Assam.
13. Persistence of FMD virus in Cattle.
14. Expression of certaincytokines inrelation to persistence of FMD virus type-O in cattle.
15. Isolation of FMD virus type-O ofbovine and porcine origin in different cell lines and molecular characterization of the adapted virus.
16. Molecular characterization of FootandMouth disease virus isolates from Assam.
1. Deka, P., Das, S., Hazarika, R. et al. (2024) Foot-and-mouth disease-associated myocarditis is age dependent in suckling calves. Scientific Report 14, 10289 (2024). https://doi.org/10.1038/s41598-024-59324-9
2. Deka, P.; Das, C.; 2 , Sharma, K.; Gogoi, S.M.; Borah, B. and Hazarika, A.K. (2018) Isolation and molecular characterisation of foot-and mouth disease virus serotype o from pigs, Indian J. Comp. Microbiol. Immunol. Infect. Dis. Vol. 39, 96-101*
3. Hosamani, M., Gopinath, S., Sreenivasa, B.P. et al. A new blocking ELISA for detection of foot-and-mouth disease non-structural protein (NSP) antibodies in a broad host range. Appl Microbiol Biotechnol 106, 6745–6757 (2022). https://doi.org/10.1007/s00253-022-12151-2
4. Baro Sangeeta, Sharma Krishna, Borah Biswajyoti, Tamuly Shantanu, Deka P., Boro Prince, Das S.K. (2018). Molecular epidemiology and phylogenetic analysis of foot and mouth disease virus type ‘O’ and evaluation of its carrier state in cattle of Assam by Real time PCR. Indian Journal of Animal Research. 53(11): 1497-1503. doi: 10.18805/ijar.B-3670.
5. B. Borah, P. Deka, K. Sharma, S. Baro, A. K. Hazarika, C. Das, G. B. Garam, P. Boro, K. Ltu, (2018) Isolation, identification and retrospective study of foot-and-mouth disease virus from affected Mithun (Bos frontalis) in north-eastern India, Transboundary and Emerging Diseases, https://doi.org/10.1111/tbed.12678, Volume65 (1)
6. Rout, M., Sharma, K., & Deka, P. (2017). Serological Evidence of Natural Exposure of Randomly Sampled Pigs of Assam to Foot-and-Mouth Disease Virus. Indian Vet. J, 94(04), 19-20.
7. Boro, P., Sharma, K., Deka, P., Sarma, R., & Sarma, S. (2016). Immune Response of Yak (Poephagus grunniens) Following Trivalent Oil Adjuvant FMD Vaccination Along With Immunomodulator. Journal of Animal Research, 6(2), 231-236.
8. Rout, M., Garam, G. B., Lama, R., Deka, P., Tripathy, J. P., Giri, P., ... & Singh, R. P. (2024). Foot-and-mouth disease in mithun, yak, cattle-yak hybrids and cattle in the north-eastern states of India during 2021-2022.
9. Rout, M., Deka, P., Nair, N.S., Karikalan, M., Manjunatha, V., Sahoo, N., Sharma, A.K., Mohapatra, J.K. and Singh, R.P. (2023). Serological Evidence of Foot-and-Mouth Disease Virus Nonstructural Protein Antibodies in Indian Elephants (Elephas maximus indicus). J. Anim. Res., 13(05): 833-837
10. P. Bordoloi, K. Sharma, R. Sharma, S. Das (2015), Application of Reverse Transcription PCR for detection of FMD virus Type "O" in infected and recovered animals, Journal of Pure 8e Applied Microbiology, 8(4):3367-3372.
11. Barman, B., Sarma, D. K., Sharma, K., & Barman, N. N. (2014). Antibody response of pigs vaccinated with FMD and swine fever vaccines*. The Indian Journal of Animal Sciences, 74(5). https://epubs.icar.org.in/index.php/IJAnS/article/view/38620
12. Govindaraj G, Ganeshkumar B, Krishnamohan A, Hegde R, Nandakumar S, Kokila Prabhakaran, Mohan V, Kakker N, Lokhande T, Sharma K, Kanani A, Limaye A, Natchimuthu K, Khan TA, Misri J, Dash BB, Pattnaik B and Rahman H. (2020). Economic Impact of FMD in cattle and buffaloes in India. Indian Journal of Animal Sciences. 90(7): 971-976.
13. G Govindaraj, A Krishnamohan, Raveendra Hegde, Nanda Kumar, Kokila Prabhakaran, Vinay Mohan Wadhwan, Naresh Kakker, T Lokhande, Krishna Sharma, Amit Kanani, K Natchimuthu, PN Ananth, Arup Kumar De, Tanveer Ahmed Khan, Jyoti Misri, BB Dash, Bramhadev Pattnaik, Rahman Habibur (2021) Foot and Mouth Disease (FMD) incidence in cattle and buffaloes and its associated farm-level economic costs in endemic India, Preventive Veterinary Medicine, 190, 105318
14. Deka, P. et al. (2022) Sampling strategy based on lesion ageing: A key concept for right sample at right time for Foot-and-Mouth disease surveillance. Conference: IAVMI 2022 At: LUVAS, Hisar
15. Deka, P. et al. (2015) Incidence, serotyping and epidemiology of Foot and Mouth disease in Assam. Conference: XXIV National Conference VIROCON 2015At: North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong.
16. Deka, P., Sharma, K., Boro, P., Baro, S., Ltu, K., Garam, G. (2016) Isolation and identificationofFMDV from clinically affected Mithun (Bosfrontalis) in north-east India., Compendium of Global Symposium on Animal health: Newer technologies and their applications and XXIXAnnual convention of IAVMI.
17. Boro, P., Baro, S., Deka, P. and Sharma, K. (2016), Retrospective study of FMD outbreaks by liquid phase blocking ELISA., Compendium of Global Symposium on Animal health: Newer technologies and their applications and XXIX Annual convention of IA VMI.
18. Baro, S., Deka, P. Sharma, K. and Boro, P. (2016), Detection of FMDV RNA in naturally infected cattle by RT-PCR, Compendium of Global Symposium on Animal health: Newer technologies and their applications and XXIX Annual convention of IA VMI.